THE URETHRAL SMEAR AS AN INDICATOR OF SEX HORMONE IN MALE RABBITS1

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Abstract
Andrews (1946) first reported the possibility of the clinical use of the urethral smear as an indicator of androgen levels in men. Cohen (1947), investigating the suggested technic further, concluded that the smear differences which Andrews recorded were due to the drying of some of the slides before fixation, and thus could not be ascribed to different androgen levels. Both Shorr (1941) and Hartman (1944) had reported previously that vaginal smears stained by the Shorr technic require immediate fixation to avoid drying effects. The work reported herein was carried out on rabbits. We utilized Andrews’ (1946) technic as described for man. Preliminary examination of about 20 normal male human urethral smears led us to conclude that the normal cells in man are largely irregularly-shaped epithelial cells with blue-green cytoplasm containing nuclei which may be compact and red-staining or vesicular and blue-to-red staining.

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