c‐fos Expression as a Model for Studying the Action of Hexachlorocyclohexane Isomers in the CNS

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Abstract
The induction of protooncogene c‐fos in the CNS after administration of several convulsants has been studied. The organochlorine insecticide γ‐hexachlorocyclohexane (γ‐HCH, lindane) has been shown to induce c‐fos expression in different brain areas. Pentylenetetrazole and picrotoxin, a known γ‐aminobutyric acid‐receptor antagonist, have also been considered. The administration of two nonconvulsant isomers of γ‐HCH, α‐HCH, and δ‐HCH, before the mentioned toxicants, affects the protooncogene expression in different ways. The differential pattern of expression displayed by c‐fos after these treatments suggests the presence of diverse mechanisms of action for the compounds studied.