Percolation and Release of Cisplatin Loaded in Poly(lactide-co-glycolide) Microspheres for Chemoembolization
- 1 April 1992
- journal article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 7 (2) , 149-160
- https://doi.org/10.1177/088391159200700203
Abstract
The dissolution kinetics, in an aqueous medium, of a water solu ble drug dispersed in an insoluble polymeric matrix, depends highly on the drug loading. A computer model of cisplatin loaded poly(lactide-co-glycolide) microspheres dissolution confirms the hypothesis that only the drug crystals connected to the surface of the microspheres are capable of dissolving through a site percolation mechanism. This behavior may also be possible with other drug release systems, limiting their use for controlled release.Keywords
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