Acetaminophen and Hepatic Necrosis

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Abstract
To the Editor: Acetaminophen in large doses is a well known cause of fulminant hepatic disease in Europe, particularly in Great Britain.1 In 1975 there were 7000 hospital admissions for acetaminophen overdose in the United Kingdom,2 with a mortality rate of 1 to 2 per cent, making this entity one of the most frequent causes of acute hepatic failure.1 Most reports have appeared in the British medical literature, where the drug is referred to as "paracetamol." The condition has been reported very rarely in the United States,3 probably partly because of a low index of suspicion and partly because . . .