ADENYLATE-CYCLASE OF HUMAN FAT-CELL GHOSTS - STIMULATION OF ENZYME-ACTIVITY BY PROSTAGLANDINS
- 1 January 1977
- journal article
- research article
- Vol. 3 (3) , 199-206
Abstract
The human fat cell adenylate cyclase is activated by prostaglandins. Of the prostaglandins tested, the E-type by causing about a 3-fold increase of enzyme activity, was more effective than the F-prostaglandins. Prostaglandin A2 had no stimulatory effect. Activation by prostaglandin E1 was not influenced by .beta.-adrenergic blockade in contrast to stimulation by epinephrine. Pretreatment of fat cells with trypsin resulted in an abolishment of PTH[parathyroid hormone]-sensitivity, but had no effect on prostaglandin responsiveness. The human fat cell adenylate cyclase is probably coupled to at least 3 distinct types of hormone receptors.This publication has 6 references indexed in Scilit:
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