Ceftibuten—in-vitro activity against respiratory pathogens, β-lactamase stability and mechanism of action
- 1 August 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 26 (2) , 209-213
- https://doi.org/10.1093/jac/26.2.209
Abstract
The in-vitro activity of ceftibuten against respiratory pathogenic bacteria was studied and compared with that of other oral β-lactam agents. Ceftibuten displayed high activity against Haemophilus influenzae and Branhamella catarrhalis. There was reduced activity against Streptococcus pneumoniae (MIC90 16 mg/l). The protein binding of ceftibuten was 77% and the primary target site PBP 3. A high degree of stability to β-lactamase hydrolysis was observed.Keywords
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