Basische Peptide des Bienengifts, II. Synthese zweier Pentapeptide aus der Sequenz des Mastzellen-degranulierenden Peptids
- 1 January 1976
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 357 (2) , 1683-1694
- https://doi.org/10.1515/bchm2.1976.357.2.1683
Abstract
The synthesis of 2 protected pentapeptides is described. The peptides are fragments of the sequence of a mast-cell-degranulating peptide from bee venom. The fragments Boc-Lys(Z)-Ile-Cys(SiPr)-Gly-Lys(Z)(I) and Boc-Pro-His(Trt)-Ile-Cys(Trt)-Arg(Tos) (II) were synthesized conventionally. The deprotection of the .alpha.-amino group by HC1/acetic acid of Boc-Ile-Cys(SiPr)-Gly-Lys(Z) was accompanied by a disulfide exchange at the cysteine residue. After the hydrolysis of fragment II with 6N HCl, allo-isoleucine could be detected by gas chromatography and amino-acid analysis.This publication has 10 references indexed in Scilit:
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