The reaction mechanism ofN-benzoylimidazole with ribonucleotides
Open Access
- 26 May 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 15 (10) , 4291-4305
- https://doi.org/10.1093/nar/15.10.4291
Abstract
The reaction of uridine 3'-phosphate with benzoylimidazole in 3' the absence and presence of a strong base was followed up by 31p and 1H nmr as well as paper electrophoresis. Possible reaction courses were proposed, the reaction rate constants were calculated and the reaction mechanism was discussed. It is possible to selectively acylate ribonucleotides with benzoylimidazole by appropriate choice of the base used.Keywords
This publication has 5 references indexed in Scilit:
- Some aspects of chemical synthesis of oligoribonucleotides.1980
- Spectrophotometric Determination of the pK Values for Dissociation of the Sugar Hydroxyls in Pyrimidine ArabinonucleosidesZeitschrift für Naturforschung C, 1975
- Synthese von Oligo‐ und Polynucleotiden, VIII. Synthese von Dinucleotiden der Ribose‐Reihe mit terminaler 3′‐Phosphat‐GruppeEuropean Journal of Organic Chemistry, 1967
- Studies on Polynucleotides. LI.1 Syntheses of the 64 Possible Ribotrinucleotides Derived from the Four Major Ribomononucleotides2Journal of the American Chemical Society, 1966
- The Effect of Substituents on the Deacylation of Benzoyl-ChymotrypsinsBiochemistry, 1962