Computer Assisted Tomography in Adrenoleukodystrophy

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Abstract
The findings on computer assisted tomography of the brain in 4 cases of adrenoleukodystrophy were sufficiently consistent to warrant delineation. Early changes, which may predate obvious clinical findings, were represented by areas of decreased attenuation coefficient in the posterior (parieto-occipital) white matter around the trigonum of each lateral ventricle. Subsequently the temporal, parietal and frontal lobes were involved, and the extensive areas of decreased attenuation coefficient in the white matter became alomst indistinguishable from the conspicuously enlarged ventricles. Only a thin ependymal wall separated the ventricular cavities from the leukomalacia lesions. Contrast medium enhancement at the periphery of the affected regions is an important, although inconsistent, feature.