USE OF CYCLOPHOSPHAMIDE AND ENHANCING SERUM TO SUPPRESS RENAL ALLOGRAFT REJECTION IN THE RAT

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Abstract
Cyclophosphamide was tested for its interaction with passive enhancement in suppressing the rejection of kidney allografts in the (DA .times. Lewis)F1 to Lewis rat strain. Dose response studies with cyclophosphamide showed that 10 mg/kg per day for 14 days was necessary for complete suppression of rejection and indefinite graft survival. Doses of 5 and 3.5 mg/kg per day had a marginal effect on graft function and survival, although the lymphocytotoxin response to the graft was completely or very substantially suppressed by smaller doses. Use of passive enhancement with cyclophosphamide at the 5- and 3.5-mg/kg per day doses resulted in a favorable interaction with improved graft function and survival. Passive enhancement in combination with 5 mg/kg per day of cyclophosphamide resulted in indefinite graft survival only if cyclophosphamide was given for 28 days. If cyclophosphamide was given for 14 days, rejection was suppressed only during cyclophosphamide treatment.