Complications of Smallpox Vaccination

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Abstract
ALTHOUGH vaccination against smallpox has been practiced in the United States since 1800, little is known in this country regarding the frequency of resulting complications. Greenberg's1 review of complications observed after the mass vaccination program in New York in 1947 constitutes essentially the only published American data concerning the frequency of complications associated with vaccination. Even in this study, however, no estimates are available regarding the numbers associated with primary vaccination and with revaccination. Published reports from several European countries have recorded such striking differences in the frequencies of complications from country to country2 3 4 5 6 that it appears that each nation's . . .

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