Vasopressin induced dysmelia in rats and its relation to amniocentesis dysmelia.

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  • 1 June 1973
    • journal article
    • Vol. 54  (3) , 291-7
Abstract
Vasopressin injected into the amniotic sac of 15½-day Sprague-Dawley rat foetuses induced limb defects. The skeletal malformations were restricted to the paws and were characterized by tapering of the digital rays. The forelimbs were more severely affected than the hindlimbs. Both of these features differed from the lesions found in amniocentesis dysmelia. Although haemorrhages are responsible for a part of the deformity in the two syndromes, the total mechanism of each must have some specific components.