THE INFLUENCE OF INFECTION ON THE CONTENT OF LYSOSOMAL ENZYMES IN RAT KUPFFER CELLS AND HEPATOCYTES

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Abstract
The activities of .beta.-glucuronidase, arylsulphatase A and acid DNase were measured in homogenates from Kupffer cells and hepatocytes prepared from germ-free, monocontaminated and conventional rats. The cells were prepared from a liver cell suspension obtained by treating the perfused liver with collagenase. Kupffer cells from germ-free rats had lower lysosomal enzyme activities than cells obtained from conventional rats. Monocontaminated animals (Escherichia coli or Streptococcus pyogenes) showed intermediate activities. The level of lysosomal enzymes in macrophages is apparently a function of the endocytic activity of these cells.

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