Regulation of lnterleukin-5 Production by Peripheral Blood Mononuclear Cells from Atopic Patients with FK506, Cyclosporin A and Glucocorticoid
- 1 January 1994
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 104 (1) , 32-35
- https://doi.org/10.1159/000236745
Abstract
Upon stimulation with phorbol ester and ionomycin, peripheral blood mononuclear cells (PBMC) of atopic patients with moderate eosinophilia produced significantly higher amounts of IL-5 compared to that of normal subjects. This finding renders further support to the notion that T cell-eosinophilic inflammation plays a central role in allergic disorders. IL·5 induction in vitro was completely inhibited by immunosuppressant FK506, cyclosporin A and dexamethasone. FK506 applied in vivo effectively suppressed clinical symptoms of atopic dermatitis and IL-5 production of PBMC. FK506 and cyclosporin A may become a better therapeutic modality against allergic diseases.Keywords
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