Pharmacological properties of amino‐oxyacetic acid in the chicken

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Abstract
1 The effects of amino-oxyacetic acid (AOAA) on the central nervous system and on skeletal muscle have been examined in the chicken. 2 AOAA had both anticonvulsant and convulsant effects, depending on the dose, as in other species. 3 The convulsant effect, accompanied by EEG spiking, decreased rapidly with increase in age of young chicks. 4 The convulsant effect was exerted primarily through supraspinal centres. 5 Of control depressants tested, only troxidone and small doses of AOAA afforded significant protection against AOAA seizures.