Silent HIV Infections

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Abstract
The report in this issue by Imagawa et al.1 that infectious human immunodeficiency virus type 1 (HIV-1) was isolated from 31 of 133 people who tested negative for antibodies on conventional enzyme-linked immunosorbent assay (ELISA) and Western blot assay adds another layer of complexity to the understanding of the epidemic of acquired immunodeficiency syndrome. The blood samples tested were from a group of homosexual men who acknowledged their continued high-risk behavior. The men were part of a much larger prospective study in which serum and lymphocytes were obtained and stored every six months.2 Twenty-seven people remained seronegative during the 7-to-36-month . . .