Inhibitory Effects of Human Leukocyte and Fibroblast Interferons on Normal and Chronic Myelogenous Leukemic Granulocytic Progenitor Cells

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Abstract
Inhibitory effects of 2 human interferon preparations, leukocyte interferon (Le-IF) and fibroblast interferon (F-IF), on granulocytic progenitor cells (CFU-C) from hematologically normal cancer patients and from patients with chronic myelogenous leukemia were evaluated. There was a wide variation in sensitivity of CFU-C to Le-IF and F-IF. F-IF was more inhibitory against CFU-C than Le-IF. Normal CFU-C and chronic myelogenous leukemia CFU-C were equally inhibited by both interferons. Effects of both interferons were neutralized by corresponding specific antisera but not by the other antisera. Differences in immunogenicity of the interferons apparently may attend their different origins.