PROTON AND POTASSIUM TRANSPORT BY H+/K+‐ATPases
- 1 December 1995
- journal article
- review article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 22 (12) , 952-960
- https://doi.org/10.1111/j.1440-1681.1995.tb02332.x
Abstract
SUMMARY: 1. H+/K+‐ATPases are members of the P‐type ATPase multigene family. The prototypical H+/K+‐ATPase is the protein that acidifies gastric luminal contents. The physiological and pharmacological significance of this pump has led to a detailed investigation of its biochemistry and molecular and cell biology.2. Recently, a number of closely related H+/K+‐ATPase isoforms have been discovered. These isoforms are present in organs other than the stomach, including the colon and kidney, where they contribute to acid—base and potassium homeostasis. The structure, expression and physiological roles of the gastric H+/K+‐ATPase and other isoforms are reviewed.Keywords
This publication has 59 references indexed in Scilit:
- Erratum: Three-dimensional cryo-electron microscopy of the calcium ion pump in the sarcoplasmic reticulum membraneNature, 1993
- Assembly of a hybrid from the α subunit of and the β subunit ofBiochemical and Biophysical Research Communications, 1992
- The family of human Na,K‐ATPase genesATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPaseFEBS Letters, 1991
- The Mechanism and Structure of the Gastric H, K-ATPaseAnnual Review of Physiology, 1990
- Isolation and characterization of gastric microsomal glycoproteins. evidence for a glycosylated β-subunit of the H+/K−-ATPaseBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1990
- The Mechanism And Structure Of The Gastric H,K-ATPaseAnnual Review of Physiology, 1990
- Activation of Apical Chloride Channels in the Gastric Oxyntic CellScience, 1989
- Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase.The Journal of cell biology, 1987
- Role of the medullary collecting duct in potassium conservationPflügers Archiv - European Journal of Physiology, 1983
- An ATPase from dog gastric mucosa: Changes of outer pH in suspensions of membrane vesicles accompanying ATP hydrolysisBiochemical and Biophysical Research Communications, 1974