A Serum Anticoagulant Factor in Systemic Lupus Erythematosus

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Abstract
The concept of lupus erythematosus as an immunologic disease is gaining popularity. Certain cases of lupus erythematosus present as hemolytic anemia, and the Coombs test may be positive in these, and indeed may reveal the presence of circulating antibodies in other cases of lupus erythematosus in which hemolysis is not apparent. A false-positive serology is also an indication of an immunologic reaction. It is of great interest, therefore, to find lupus erythematosus associated with any other immunologic phenomenon. Recently the attention of hematologists has been drawn to a small number of patients with a hemorrhagic disturbance due to a circulating anticoagulant. There is evidence that in some of these cases the anticoagulant is formed by an immunologic process. Craddock and Lawrence have reported the development of an anticoagulant in hemophilia following repeated therapy with blood, plasma, or antihemophilic globulin.1 Several anticoagulant factors have been

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