Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo.
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (1) , 73-76
- https://doi.org/10.7164/antibiotics.40.73
Abstract
The antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC30, 1.5 .mu.g/ml) and L1210 murine leukemia cells (IC50, 2.2 .mu.g/ml). Acetomycin also had marked activity in the human tumor stem cell assay, with a 33% overall response rate (.ltoreq. 30% survival) against 49 primary tumors. However, acetomycin was inactive in four in vivo tumor assay systems (L1210 and P388 leukemias, B16 melanoma and the MX-1 mammary xenograft system). This lack of in vivo activity may result from metabolic inactivation of acetomycin.This publication has 5 references indexed in Scilit:
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