Roles of histone acetyltransferases and deacetylases in gene regulation
- 7 December 1998
- Vol. 20 (8) , 615-626
- https://doi.org/10.1002/(sici)1521-1878(199808)20:8<615::aid-bies4>3.0.co;2-h
Abstract
Acetylation of internal lysine residues of core histone N‐terminal domains has been found correlatively associated with transcriptional activation in eukaryotes for more than three decades. Recent discoveries showing that several transcriptional regulators possess intrinsic histone acetyltransferase (HAT) and deacetylase (HDAC) activities strongly suggest that histone acetylation and deacetylation each plays a causative role in regulating transcription. Intriguingly, several HATs have been shown an ability to acetylate nonhistone protein substrates (e.g., transcription factors) in vitro as well, suggesting the possibility that internal lysine acetylation of multiple proteins exists as a rapid and reversible regulatory mechanism much like protein phosphorylation. This article reviews recent developments in histone acetylation and transcriptional regulation. We also discuss several important, yet unanswered, questions. BioEssays 20:615–626, 1998. © 1998 John Wiley & Sons Inc.Keywords
This publication has 87 references indexed in Scilit:
- Yeast TAFII145 Functions as a Core Promoter Selectivity Factor, Not a General CoactivatorCell, 1997
- mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in DrosophilaThe EMBO Journal, 1997
- The Transcriptional Coactivators p300 and CBP Are Histone AcetyltransferasesPublished by Elsevier ,1996
- Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: redundant and position-independent functions in assembly but not in gene regulation.Genes & Development, 1996
- Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor SuperfamilyScience, 1995
- Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding ProteinPublished by Elsevier ,1995
- Yeast TAF IIS in a multisubunit complex required for activated transcriptionNature, 1994
- An RNA polymerase II holoenzyme responsive to activatorsNature, 1994
- Nucleosome Structural Changes Due to AcetylationJournal of Molecular Biology, 1994
- Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.Genes & Development, 1993