Sarcoma-Producing Cell Lines Derived from Clones Transformed in vitro by Benzo[ a ]pyrene
- 29 August 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3896) , 917-918
- https://doi.org/10.1126/science.165.3896.917
Abstract
Cells derived from mixed Syrian hamster embryo cultures were treated with pyrene (control) or with benzo[a]pyrene. Transformed clones were obtained only with the carcinogen. Some of the transformed clones were responsible for cell lines that produced tumors when injected into hamsters. These observations provide evidence that chemical-induced oncogenesis can be studied by an in vitro model.Keywords
This publication has 4 references indexed in Scilit:
- Studies with carcinogens and tumor-promoting agents in cell cultureExperimental Cell Research, 1968
- Properties of Syrian hamster cells transformed in the presence of carcinogenic hydrocarbonsExperimental Cell Research, 1967
- Malignant Transformation of Hamster Embryonic Cells by 4-Hydroxyaminoquinoline N-oxide in Tissue CultureThe Tohoku Journal of Experimental Medicine, 1967
- CLONAL GROWTH OF MAMMALIAN CELLS IN VITROThe Journal of Experimental Medicine, 1956