Elevation of serum corticosterone in rats by bremazocine, a κ-opioid agonist
- 1 May 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (5) , 345-346
- https://doi.org/10.1111/j.2042-7158.1984.tb04392.x
Abstract
Bremazocine at doses of 0·01 mg kg−1 s.c., and higher, increased serum corticosterone concentration several-fold in rats. The increase occurred within 20 min, was maximum at 40–60 min and subsided after 120 min. Pretreatment with naloxone (1–10 mg kg−1 s.c.) antagonized the corticosterone increase. These data support the view that κ-opioid agonist activity of bremazocine mediated the corticosterone increase.Keywords
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