EFFECT OF ANTI-ANDROGENS ON THE UPTAKE AND BINDING OF ANDROGEN BY HUMAN BENIGN NODULAR PROSTATIC HYPERPLASIA IN VITRO

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Abstract
The effect of anti-androgenic compounds on the uptake and binding of androgen in human benign nodular prostatic hyperplasia was studied in vitro. The two anti-androgenic compounds, Cyproterone (1,2α-methylene-6-chloro-4,6-pregnadien-17α-ol-3,20-dione) and 17α-methyl-β-nortestosterone (SK & F 7690) were both capable of reducing the uptake of 3H-labelled testeosterone. In four patients, the average reduction caused by Cyproterone was 27 per cent and by 17α-methyl-β-nortestosterone 38 per cent. These two compounds were also capable of reducing the formation of androgen-macromolecular complexes both in the cytosol and in nuclei obtained from prostatic homogenates.

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