Factors Affecting Development of Hypertensive Vascular Disease After Renal Injury in Rats.

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Abstract
Correlations between renal excretory function phenolsulfonphthalein excretion, osmolal concentration of urine, and blood area nitrogen, renal mass and hypertension were studied in 17 rats which had been subjected to a figure-of-eight tie of one kidney and contralateral nephrectomy. In addition, 9 of the animals were exposed to the stress of a psychological disturbance. All 17 animals became hypertensive and all had some impairment of excretory renal function. However, the degree of impairment of renal function did not correlate with the level of blood pressure. Hypertrophy of remaining renal tissue was marked but did not prevent functional impairment or blood pres-. sure elevation. The noxious psychological stimulus appeared to worsen the manifestations of the hypertensive process.