Antioxidative activities of tocotrienols on phospholipid liposomes

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Abstract
Antioxidative activity of tocotrienol (Toc3) was studied in the oxidation of dilinoleoylphosphatidylcholine (DLPC) liposomes. The objective was to measure the differences in the antioxidative activities betweenα‐Toc3 andα‐tocopherol (α‐Toc), and betweenγ‐Toc3 andγ‐Toc. When each antioxidant was added to the already prepared DLPC liposome solution, the antioxidative activity of Toc3 was larger than that of Toc. However, when incorporated into the liposomal membrane, the antioxidative activities of Toc3 and Toc were the same and were intermediate between those of the added Toc3 and Toc.When added to the liposome solution, the consumption of Toc3 during the induction period was larger than that of Toc. When incorporated into the liposomal membrane, the consumptions of Toc3 and Toc were the same and were intermediate between those of the added Toc3 and Toc.These results suggest that the reactions of Toc3 and Toc with phospholipid peroxide within the membrane are inhibited to a different degree depending on the dosing manner of Toc3 and Toc. Namely, the degree of inhibition decreases in the following order: Toc(added)> Toc(incorporated)= Toc3(incorporated)> Toc3(added).

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