Studies on the Biosynthesis of Antibiotics1

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Abstract
The biosynthesis of a number of antibiotics which have been studied in this laboratory is reviewed. These include indolmycin, pyrrolnitrin, dihydrophenylalanine, spectinomycin, chlorothricin, α–naphthocyclinone and granaticin. The results on the stereochemistry of some reactions involved in these biosyntheses are also discussed and these include the stereochemical course of the transfer of a methyl group from S–adenosylmethionine to the β–carbon of indolepyruvate and the stereochemistry of the reductive removal of the hydroxyl functions in the formations of 2,6–dideoxyhexoses.