THE BCG‐INDUCED RESISTANCE TO LISTERIOSIS

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Abstract
BCG immunization schedules for the demonstration of resistance to listeriosis in C3H mice were re‐evaluated in a series of experiments. A two‐step procedure was found to be superior to a one‐step vaccination schedule. Reactivation with BCG five days before challenge caused a significant depression of the multiplication of Listeria monocytogenes in the spleen. A saline extract of tubercle bacilli was able to reactivate the BCG immunization in the “same way, even though a transient non‐immunogenic effect of the same extract was also demonstrated. In the two‐step procedure the vaccination dose was found to play a minor role, whereas the reactivation was dose‐dependent.

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