Localisation of xanthine oxidase to synovial endothelium.
Open Access
- 1 November 1991
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 50 (11) , 760-762
- https://doi.org/10.1136/ard.50.11.760
Abstract
The presence of the xanthine oxidase enzyme system has been demonstrated in the rheumatoid synovium. This supplies a reactive oxygen species generating system to synovium that is subjected to hypoxic-reperfusion cycles (cf inflamed rheumatoid synovium). An antibody to bovine milk xanthine oxidase has been used to localise the enzyme by immunohistochemistry to synovial endothelium. This implicates the endothelial cell as playing a major part in exacerbations of synovitis, induced by radicals.Keywords
This publication has 9 references indexed in Scilit:
- Influence of disodium aurothiomalate on the activities of xanthine dehydrogenase and xanthine oxidase in endothelial cells.1991
- SUPEROXIDE RADICAL GENERATION BY INFLAMED HUMAN SYNOVIUM AFTER HYPOXIAThe Lancet, 1989
- HYPOXIC-REPERFUSION INJURY IN THE INFLAMED HUMAN JOINTThe Lancet, 1989
- Xanthine oxidoreductase is present in human synovium.Annals of the Rheumatic Diseases, 1987
- Inhibition of human endothelial cell proliferation by gold compounds.Journal of Clinical Investigation, 1987
- Is chronic synovitis an example of reperfusion injury?Annals of the Rheumatic Diseases, 1986
- Significance of xanthine oxidase in capillary endothelial cells.1986
- Preparation of Bovine Milk Xanthine Oxidase as a Dehydrogenase FormThe Journal of Biochemistry, 1982
- The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzymeBiochemical Journal, 1972