Direct1H n.m.r. observation of the cell-free conversion of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine and δ-(L-α-aminoadipyl)-L-cysteinyl-D-(–)-isoleucine into penicillins
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 917-919
- https://doi.org/10.1039/c39810000917
Abstract
The cell-free conversion of δ-(L-aminoadipyl)-L-cysteinyl-D-(–)-isoleucine (lb) into a penicillin (2b) was observed directly by 1H n.m.r. spectroscopy and the thiazolidine ring formation was shown to occur with retention of stereochemistry at C-3 of the isoleucinyl residue by 1H nuclear Overhauser enhancement studies of the product penicillin in the deproteinated incubation mixture.Keywords
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