Interaction of Stretch and Ryanodine on Oxygen Uptake in the Rat Diaphragm

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Abstract
The relation between oxygen consumption, length and tension of isolated strips of rat diaphragm was examined as a function of the concentration of ryanodine. The influence of mechanical stretching on oxygen consumption of resting rat diaphragm was found to be very small compared with that reported in Rana temporaria There is evidence that the stretch response is related to an increase in length rather than to rise in tension; the latter per se may have a negative influence on Qo2. Ryanodine causes a small but definite rise in Qo2; in contrast to frog muscle, no significant difference was observed between muscles maintained isometrically and those which were allowed to shorten. The limited observations which have been made on different species are consistent with the possibility that the Qo2 responses to stretch and to ryanodine may involve a common mechanism.

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