Algorithm to control "effect compartment" drug concentrations in pharmacokinetic model-driven drug delivery
- 1 January 1993
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Engineering
- Vol. 40 (10) , 993-999
- https://doi.org/10.1109/10.247797
Abstract
In most computer-controlled pharmacokinetic model-driven drug infusion pumps, simulation of a linear compartmental pharmacokinetic model is used to compute the rate of intravenous drug infusion required to achieve setpoint central compartment (plasma) drug concentrations. For many drugs, it has been suggested that it is the drug concentration in a hypothetical "effect" compartment, rather than in the plasma, that should be manipulated to achieve maximum control over pharmacologic action. Controlling the effect compartment drug concentration is algorithmically more difficult than controlling the central compartment drug concentration because of the time delay between administration of drug into the central compartment and its subsequent appearance in the effect compartment. Presented in this paper is a model-based dosing algorithm for use in pharmacokinetic model-driven drug infusion devices that target the theoretical effect compartment drug concentration.Keywords
This publication has 17 references indexed in Scilit:
- Holford NHG and Sheiner LB “Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models”, Clin Pharmacokin 6:429–453 (1981)—The BackstoryThe AAPS Journal, 2011
- Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pumpJournal of Pharmacokinetics and Biopharmaceutics, 1992
- A simple analytical solution to the three-compartment pharmacokinetic model suitable for computer-controlled infusion pumpsIEEE Transactions on Biomedical Engineering, 1991
- Pharmacokinetics, Pharmacodynamics, and Rational Opioid SelectionAnesthesiology, 1991
- Understanding Pharmacokinetics and Pharmacodynamics Through Computer SimulationAnesthesiology, 1990
- Two Equally Valid Interpretations of the Linear Multicompartment Mammillary Pharmacokinetic ModelJournal of Pharmaceutical Sciences, 1990
- COMPUTER CONTROLLED INFUSION OF PROPOFOLBritish Journal of Anaesthesia, 1989
- Total intravenous anaesthesia with propofol and alfentanil by computer‐assisted infusionAnaesthesia, 1988
- Testing Computer-controlled Infusion Pumps by SimulationAnesthesiology, 1988
- Decreased Fentanyl and Alfentanil Dose Requirements with Age. A Simultaneous Pharmacokinetic and Pharmacodynamic EvaluationSurvey of Anesthesiology, 1987