Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia
Open Access
- 19 November 2007
- journal article
- case report
- Published by Wiley in Pediatric Blood & Cancer
- Vol. 50 (1) , 142-145
- https://doi.org/10.1002/pbc.20902
Abstract
We describe a female with a history of autosomal recessive hyper‐IgM (HIGM) syndrome along with a history of autoimmune hemolytic anemia and intermittent lymphadenopathy. She subsequently developed neutropenia, lymphocyostosis and mild thrombocytopenia. Flow cytometry of the peripheral blood revealed the presence of a marked predominance of cytotoxic T lymphocytes, shown to be clonal, with concomitant natural killer (NK) antigen expression. She responded to weekly methotrexate therapy. Pediatr Blood Cancer 2008;50:142–145.Keywords
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