ATP-Binding Cassette Transporter G8 Gene As a Determinant of Apolipoprotein B-100 Kinetics in Overweight Men
- 1 November 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 24 (11) , 2188-2191
- https://doi.org/10.1161/01.atv.0000143532.93729.d6
Abstract
Objective— We examined the influence of genetic variation of the ATP-binding cassette (ABC) transporter G8 on apolipoprotein B (apoB) kinetics in overweight/obese men. Methods and Results— Very low... This study demonstrates that subjects carrying the ABCG8 400K allele had lower production rate of VLDL–apoB and higher VLDL to LDL–apoB conversion. The production rate and fractional catabolic rate...Keywords
This publication has 20 references indexed in Scilit:
- Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivityJournal of Lipid Research, 2004
- ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatinJournal of Lipid Research, 2004
- Inheritance of cholesterol metabolism of probands with high or low cholesterol absorptionJournal of Lipid Research, 2002
- Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterolJournal of Clinical Investigation, 2002
- Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surfaceJournal of Clinical Investigation, 2002
- Low density lipoprotein receptor (LDLR) gene mutations in Canadian subjects with familial hypercholesterolemia, but not of French descentHuman Mutation, 2001
- Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorptionNature Genetics, 2001
- Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC TransportersScience, 2000
- Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects.Journal of Clinical Investigation, 1991
- Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1990