Diazacholesterol Myotonia: Accumulation of Desmosterol and Increased Adenosine Triphosphatase Activity of Sarcolemma
- 2 March 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4076) , 910-912
- https://doi.org/10.1126/science.179.4076.910
Abstract
Myotonia induced in rats by 20,25-diazacholesterol is accompanied by accumulation of desmosterol in serum, fragmented sarcoplasmic reticulum, and sarcolemma. Activities of (Na + ,K + )- and Ca 2+ -stimulated adenosine triphosphatases of the sarcolemma are increased, but not the Mg 2+ -stimulated adenosine triphosphatase. The altered sterol composition of the sarcolemma may cause this type of myotonia by decreasing the chloride conductance of the membrane.Keywords
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