Histocompatible Embryonic Stem Cells by Parthenogenesis
- 26 January 2007
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 315 (5811) , 482-486
- https://doi.org/10.1126/science.1133542
Abstract
Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation. After parthenogenetic activation of murine oocytes and interruption of meiosis I or II, we isolated and genotyped pES cells and characterized those that carried the full complement of major histocompatibility complex (MHC) antigens of the oocyte donor. Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients, demonstrating that selected pES cells can serve as a source of histocompatible tissues for transplantation.Keywords
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