Modulation of Pulmonary Inflammation after Endotoxin Inhalation with a Platelet-Activating Factor Antagonist (48740 RP)
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 86 (3) , 303-307
- https://doi.org/10.1159/000234588
Abstract
An acute pulmonary response was induced in guinea pigs and hamsters by inhalation of bacterial endotoxin in the form of a purified lipopolysacchande (LPS). Pretreatment with the platelet-activating factor (PAF) antagonist, 48740 RP, inhibited damage to endothelial cells, decreased vascular permeability and the number of neutrophils in the airways 24 h after exposure to LPS. The increase in the number of platelets in the airways caused by endotoxin was not affected. The results suggest that PAF modulates early inflammation after endotoxin inhalation.Keywords
This publication has 19 references indexed in Scilit:
- Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits : Studies with FR-900452, a specific inhibitor of PAFThrombosis Research, 1986
- Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells.Journal of Clinical Investigation, 1986
- Morphometric changes of the lung induced by inhaled bacterial endotoxinExperimental and Molecular Pathology, 1985
- ENDOTOXIN IN COTTON DUST AND RESPIRATORY-FUNCTION DECREMENT AMONG COTTON WORKERS IN AN EXPERIMENTAL CARDROOMPublished by Elsevier ,1985
- Acute Bronchoconstriction Induced by Cotton Dust: Dose-Related Responses to Endotoxin and Other Dust FactorsAnnals of Internal Medicine, 1984
- The release of platelet-activating factor from human endothelial cells in culture.The Journal of Immunology, 1983
- Platelet-activating factor effects on pulmonary ultrastructure in rabbitsExperimental and Molecular Pathology, 1983
- PLATELET SEROTONIN RELEASE BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES STIMULATED BY COTTON DUST BACTERIA1983
- Further studies on inhaled endotoxin-containing bacteriaEnvironmental Research, 1982
- LUNG CELL REACTIONS AFTER INHALATION OF BACTERIAL LIPOPOLYSACCHARIDES1982