Localisation of a gene for chondrocalcinosis to chromosome 5p
- 1 July 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Molecular Genetics
- Vol. 4 (7) , 1225-1228
- https://doi.org/10.1093/hmg/4.7.1225
Abstract
Chondrocaicinosis is a common disorder which may associate with acute and chronic arthritis. A familial form, inherited as an autosomai dominant trait, has been mapped In a iarge famiiy in which affected members aiso suffer recurrent fits in childhood. The gene which causes this disease shows linkage with several poiymorphic markers on chromosome 5p with a maximum multipoint lod score of 4.6 between D5S810 and D5S416. Mapping a iocus for chondrocalcinosis will allow the heterogeneity of the disorder to be assessed and may also be relevant to understanding the aetiology of osteoarthritis with which it commoniy associates.Keywords
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