LEPTOSPIRES COLONIAL VARIATIONS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 243  (4) , 511-521
Abstract
Six of 12 relatively freshly isolated and museum strains were heterogeneous in colonial morphology. Recloned colonial variants of one and the same heterogeneous populations did not exhibit any differences in antigenic properties. Distinctions in virulence (LD50) for hamsters were marked. Differences in the level of renal infection (ID50) and in the morphology of the cells (hooked and straight) were also found. In a Tween-80-albumin medium, mutants appeared without any changes in antigenic properties, virulence and cell morphology at a frequency of 10-9 to 10-8/bacterium per generation.

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