Prostaglandins and Inflammatory Cell Movement in vitro
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 56 (6) , 500-506
- https://doi.org/10.1159/000232065
Abstract
The prostaglandins PGEl5 E2, F2α, and A1had no significant cell migration inhibitory or chemotactic activity for guinea pig peritoneal exudate cells when tested in vitro using respectively the capillary tube cell migration test and the Boyden chamber test for chemotaxis. PGE1 and PGE2 also did not affect the positive chemotactic action of lymphokine. The proposed role of prostaglandins as chemotactic agents in inflammatory responses therefore should be treated with some caution.Keywords
This publication has 2 references indexed in Scilit:
- Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid.Journal of Clinical Investigation, 1977
- Release of prostaglandins from human polymorphonuclear leukocytesInflammation, 1975