Effects of selective dopamine D1 and D2 antagonists on male rat sexual behavior
- 1 October 1990
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 46 (10) , 1026-1028
- https://doi.org/10.1007/bf01940663
Abstract
The effects of selective dopamine (DA) D1 and D2 antagonists on male rat sexual behavior were investigated. The D1 antagonist (+)SCH-23390, 25–100 μg kg−1 s.c. −20 min, and the D2 antagonist raclopride, 0.1–1.6 mg kg−1 s.c., −20 min, decreased both the number of mounts and intromissions preceding ejaculation. No statistically significant effects in the time up to ejaculation or in the time up to the first intromission were noted, whereas both compounds produced a statistically significant increase in the post-ejaculatory interval. The effect can generally be characterized as psychomotor inhibition, and no evidence was obtained for a specific role of DA D1 or D2 receptors in the mediation of male rat sexual behavior.Keywords
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