Solid Phase Synthesis of 2′, 5′-Oligoadenylates Containing 3′-Fluorinated Ribose
- 1 August 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 14 (6) , 1259-1267
- https://doi.org/10.1080/15257779508010689
Abstract
2′, 5′-phosphodiester bond-linked oligoadenylate trimers with 3′-fluoro-3′-deoxyadenosine residues incorporated at specific positions of the nucleotide sequence were synthesized by the solid phase phosphite triester (phosphoramidite) method. The syntheses were in the 2′ to 5′ direction and were performed manually using commercially available microcolumns. The oligonucleotides were 5′-end phosphorylated on the support before deprotection.Keywords
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