Haptenic Properties of Paralytic Shellfish Poison Conjugated to Proteins by Formaldehyde Treatment

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Abstract
Summary Paralytic shellfish poison, conjugated to protein by formaldehyde condensation, was shown to possess haptenic properties, as demonstrated by passive hemagglutination and mouse protection tests with anti-sera obtained from rabbits immunized to PSP-HCHO-BSA. The anti-PSP produced to PSP-HCHO-BSA was of low potency. Hap-tene inhibitions suggest, however, that the antisera may be satisfactory for sensitive and specific detection of PSP in contaminated shellfish and their marine environment.

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