Hit-and-Run Neutralization of Poliovirus
- 1 November 1985
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 66 (11) , 2495-2499
- https://doi.org/10.1099/0022-1317-66-11-2495
Abstract
At physiological ionic strength, monoclonal antibody 35-1f4 has previously been shown to neutralize poliovirus type 1 by antibody-mediated polymerization. At low ionic strength, this antibody neutralized the virus by a hit-and-run mechanism: the virions were converted to non-infectious, empty capsids devoid of antibodies. These empty capsids resembled those formed by thermal denaturation of native polio virions in their sedimentation coefficient (80S), antigenicity (H) and isoelectric pH (6.3).Keywords
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