EXPERIMENTALLY INDUCED INFECTIOUS BOVINE KERATOCONJUNCTIVITIS - EFFECTIVENESS OF A PILUS VACCINE AGAINST EXPOSURE TO HOMOLOGOUS STRAINS OF MORAXELLA-BOVIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (10) , 1519-1522
Abstract
A study was conducted to determine whether vaccination with sonicated pili of M. bovis would protect cattle from subsequent infection and disease when experimentally challenged by exposure to homologous cultures of M. bovis. Some calves were i.m. inoculated 2 times with pili of M. bovis suspended in water, and others were s.c. inoculated 2 times with pili of M. bovis suspended in oil; 21 days were allowed between inoculations. Controls were nonvaccinated calves. At 14 days after the last inoculation all calves were exposed to virulent homologous cultures of M. bovis. Vaccination with sonicated pili of M. bovis may induce protective immunity against homologous strain challenge exposure. Vaccines in oil that were injected s.c. protected to a greater extent than did vaccines in water that were injected i.m. The development of inflammatory nodules at the site of inoculation was associated with resistance to infection and disease. Only 1 of the vaccinated calves that resisted disease lacked precipitating antibodies against sonicated pili at the time of the challenge exposure. This calf had antibodies 2 wk later.

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