THE METABOLISM OF PROSTAGLANDIN E2 BY TISSUES FROM THE HUMAN UTERUS AND FOETO-PLACENTAL UNIT

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Abstract
The biosynthesis and metabolism of prostaglandin [PG] E2 was studied in cell-free homogenates of tissues from the uterus and feto-placental unit using specific in vitro methods. The synthesis of PGE2 is greater in endometrial tissue from the secretory phase (53.07 .+-. 39.05; ng/100 mg wet tissue/h) than from the proliferative phase of the uterine cycle. Endometrial tissue forms more of this compound than myometrium (P < 0.005). During early pregnancy, synthesis is decreased (25.10 .+-. 16.62); at term, myometrium produces more PGE2 than decidua. During labor, however, decidual tissue accumulates more of this compound (52.73 .+-. 18.04) than either myometrium (34.71 .+-. 13.19) or cord (28.63 .+-. 11.71). The catabolic enzymes are most active in the placenta and chorion, followed by the cord, myometrium, decidua and amnion, but the differences have only a slight effect on the amounts of PGE2 which remain at the end of the incubation. The results suggest a high turnover of PGE2 in the decidua, myometrium and cord.

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