Palladium-catalysed 1,4-arylation/alkylation of buta-1,3-diene with halogenoarenes and stabilised anions
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 647-651
- https://doi.org/10.1039/p19900000647
Abstract
In the presence of a palladium–phosphine catalyst, buta-1,3-diene reacts with halogenoarenes and –CH(CN)2 to give 1,4-arylation/alkylation products of the diene, ArCH2CHCHCH2C(Ar)(CN)2(6), in moderate yields. In this reaction, two carbon–carbon bonds are built up from three components by a tandem insertion/coupling reaction in one catalytic cycle. Stabilised anions such as –CH(CN)CO2Me and –CH(CO2Et)2 similarly yield 1,4-arylation/alkylation products.Keywords
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