Abstract
Two patients who developed widespread severe avascular necrosis of bone while on steroid replacement therapy are described. One, a diabetic, underwent V-90 pituitary ablation for retinopathy and developed avascular necrosis within 18 mo. of starting prednisolone. The other, who had Addison''s disease, developed avascular necrosis within 14 mo. of starting cortisol replacement therapy. Both cases came to bilateral total hip replacement.