Kinetic Studies on the Methylation of Thiopurines
- 1 January 1963
- journal article
- research article
- Published by Wiley in Israel Journal of Chemistry
- Vol. 1 (4) , 477-482
- https://doi.org/10.1002/ijch.196300061
Abstract
Both 6‐mercaptopurine and 6‐thioxanthine, when treated with methyl iodide in dimethylformamide, undergo a two‐step reaction, i.e. first methylation at the sulphur atom, followed by alkylation at N‐3. Reaction; at the sulphur atom of 3‐methyl‐6‐purinethione proceeds 1350 times faster than in 6‐mercaptopurine.Keywords
This publication has 2 references indexed in Scilit:
- Synthesis and Properties of 3-Methylpurines1The Journal of Organic Chemistry, 1961
- RESEARCHES ON PURINES. XVIPublished by Elsevier ,1915