Selenium Sulfide: Adjunctive Therapy for Tinea Capitis

Abstract
Selenium sulfide lotion used as a shampoo is an effective adjunctive agent to griseofulvin in the treatment of tinea capitis. Of 16 children with Trichophyton tonsurans infections, 15 had negative fungal cultures at 2 wk following a regimen of daily oral griseofulvin and selenium sulfide shampooing twice weekly. All patients treated with griseofulvin alone or in combination with either a bland shampoo or topical clotrimazole had positive cultures not only at the 2-wk interval but also as long as 8 wk later. In vitro analysis shows selenium sulfide to be sporicidal, correlating well with the in vivo observations. It is postulated that selenium sulfide usage may lessen the chances for spreading of infectious spores to other individuals.

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